Rem Saverem

Her last name seems to say, "Save Them".
Her first name resembles the acronym of "Lunar Excursion Module".
In the manga, her name is written "Seibrem".
An unsupported theory is that, miraculously, Rem also survived the crash landing and was separated from Vash and Knives. This could be suggested by Meryl sporting a slight resemblance, and her describing her grandmother, a woman who has similarities to Rem.

Rem firmly believes Rowan would not have shot her and expresses this to the captain. Knives comes alone to the captain, who is saddened by the uncertainty of his actions. Knives shows no sympathy and execute his plot by shooting and murdering the captain. He then sets the entire SEEDS fleet course for a crash landing on Gunsmoke, thus destroying the remains of the human race. Knives return to Rem and Vash, and they make their way to the escape pods. Rem, however, stays behind believing she can save the surviving flee members. She leaves the boys in the pod and deploys it. Vash cries desperately for Rem to stay but she comforts him and tells him, "Take care of Knives." Whether Rem was aware of Knives plot is uncertain, but after the pod deploys Vash, he watches the ship explode with Rem onboard. Knives glares on with a deviant smile but is shocked when the SEEDS fleet miraculously begins to change course. Rem was able to redirect the fleet before the ship exploded, resulting in her untimely demise.

Rem is motivated to join Project SEEDS in hope for a better future after grieving the death of her lover, Alex. During a SEEDS mission, her crew discovers two male Plants. The crew members decide the best course of action is to eliminate them, but Rem stands in their way and convinces them to spare their lives. The two Plants come to be named Vash and Knives. Rem becomes the boys' caretaker and in one year they grew to the size of adolescent teens. Around this time, the crew celebrates their discovery of the planet Gunsmoke. Rem continues to teach the boys the value of life and the virtues of never hurting another being. This strongly influences Vash, who carries these teachings throughout his life.

However, the abuse from a fellow crew member, Steve, leads Knives to believe Rem's philosophy is nonsense and he begins to grow spiteful of humans. In his rage, Knives comes to the conclusion that the crew members must be exterminated as revenge. As part of his plot to do so, Knives comes to crew members Mary and Rowan with a plan to remove Steve by falsely claiming that he raped Mary. Despite Rem's pleas for Steve to stand a fair trial, the court orders him frozen and locked in cryostasis. Afterward, Rowan proposes to Mary and reveals he has rigged Steve's freezer to kill him. Mary is shocked by his actions and refuses, causing Rowan to go insane and repeatedly shoot her. Rem and the boys discover them, and Rem tries to calm Rowan to stop him, however, the crew's captain, fearing Rem will be shot, opens the ship's cargo hatch and plunges Rowan and Mary's body into space, killing them.

Rem was noted for her compassion and benevolence. She deeply cared for Vash and Knives, going as far to sacrifice herself to save them. She was also a pacifist who did not like violence and tried to teach the two boys the value of life and the virtues of non-violence.

Rem had long black hair and brown eyes. She wore a plain white t-shirt, blue pants, and shoes.