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The Contamination: The inhabitants of Hell contract a strange and aggressive virus that prevents normal rebirth, causes physical mutations or decomposition, and transforms beloved characters into hostile or tragic figures.

Dissemination by Powers: Powerful evil beings and demons can transmit the virus inadvertently or intentionally using their unique abilities—such as Vox spreading it through digital screens or Alastor via radio.

Tragic Choices: Fan-made animations and stories often focus on painful decisions, such as characters like Husk having to amputate infected limbs to stop the spread, or undergoing complex medical surgeries to cure them.

Angelic Involvement: Some variations of the story attribute the creation or release of the virus to Heaven (such as Lute or Sera) as a new, more permanent form of extermination.

The Cure: Characters like Carmilla Carmine frequently attempt to use rare, nutrient-rich immune blood to synthesize a surgical cure in secret laboratories.

Immunity: Charlie Morningstar and some high-ranking Overlords are generally portrayed as immune to, or possessing, special blood capable of killing the virus.

Patient Zero: In many fan interpretations, figures like Alastor become initial or primary targets of the plague.

Stage 1 (Initial Exposure and Wounds): Victims contract the virus through attacks or contact with angels. Early signs include painful sores, weakness, and unusual discoloration of the skin or body.

Stage 2 (Mutation and Physical Change): The body begins to deform. Limbs or hands darken, take on claw-like shapes, and undergo severe mutations. Characters experience mood swings, physical pain, and fear of losing control.

Stage 3 (Loss of Control and Violence): Mental faculties deteriorate. Infected individuals experience uncontrollable violence, aggressive impulses, and a hypnotic state in which they attack close friends.

Stage 4 (The Mindless Monster): The final stage completely eliminates the victim's original personality. They become an aggressive, flesh-hungry monster, driven only by the desire to spread the infection.