Kim Possible

Anne Possible (Kim's mother) - actress Alyson Hannigan. A neurosurgeon with a black belt. She has red hair and is a kind and caring mother who is ready to join Kim and Ron on a life-saving mission.

James Possible (Kim's Dad) - Actor Matt Clark Kim's father, a rocket scientist.

Nana Possible (Kim's Grandmother) - actress Connie Ray Kim's maternal grandmother. A kind elderly woman.

Jim and Tim are twins, the younger brothers of Kim (actors Owen and Connor Fielding).

Bonnie Rockwaller (actress Erica Tam): Kim's classmate and rival. In the film, she's Asian with long black hair, a typical "naughty girl" who cares about school hierarchy and popularity.

Poppy Blue (actress Christy Carlson Romano) has a small role. Christy Carlson Romano is the original voice actress for Kim in the animated series, and her appearance in the film is a fun Easter egg for fans.

Mr. Barkin - Actor Michael P. Northey Schoolteacher.

Dr. Drakken (Todd Stashwick) is a tall man in a blue lab coat with black hair slicked back. Unlike the animated series, where Drakken has completely blue skin, the creators decided to make him more "realistic" in the film: instead of solid blue skin, he has a bluish tint to his face with visible blue veins. The directors explained this as if an experiment had gone wrong and left a side effect. He also has a smaller version of himself in the film—Little Drakken (Maxwell Simkins).

Shego is played by Taylor Ortega. She's a tall, slender brunette with long black hair. She wears green eyeshadow and dark lipstick. She wears a black and green bodysuit—the color scheme is retained from the animated series. However, her skin in the film isn't green, as in the animation, but a normal shade. Director Adam Stein explained that the original costume looked "like pajamas" in live-action, so they redesigned it.

Professor Dementor, played by actor Patton Oswalt, is a villain who appears in the film's action-packed prologue. He has a German accent and is outraged by "pink and glitter." Patton Oswalt is the same actor who voiced Dementor in the animated series.

Possible Option Team
Kim Possible - actress Sadie Stanley. A teenage girl with shoulder-length red hair and green eyes. Unlike the animated series, where Kim wore a midriff-baring top, in the film her costume is more covered and practical—a purple and black combat uniform with no exposed midriff. At school, she wears regular teenage clothes. In the film, Kim is just starting high school and plays football, not cheerleading.

Ron Stoppable (portrayed by Sean Giambrone) is a short, blond guy with tousled hair. He wears oversized, baggy clothes—a typical nerd. His voice is more nasal than in the animated series. In the film, Ron is the classic awkward sidekick, accidentally pressing self-destruct buttons and constantly getting into awkward situations.

Rufus — voiced by Nancy Cartwright. A naked mole rat, Ron's pet. In the film, Rufus isn't purchased from a store, but rather found as an adult in a lab by Ron. He is a CGI character, pink in color, just like in the animated series. Nancy Cartwright is the same actress who voiced Rufus in the original animated series.

Wade (actor Issac Ryan Brown) is a young black boy, a child prodigy, and a computer genius. Despite his age, he already has a college education. He provides Kim and Ron with gadgets and information, rarely leaving his room.

Athena (actress Ciara Wilson) is a new character created specifically for the film. A teenager who arrives at Middleton High School and quickly becomes friends with Kim, even surpassing her in combat skills, much to Kim's annoyance. It is later revealed that Athena is an android created by Drakken to infiltrate Kim's life and replicate her abilities. After Drakken's lair is destroyed, Kim and Ron repair her and reprogram her for good.

Sadie Stanley Kim Possible
Sean Giambrone Ron So-so
Alyson Hannigan, Anne Possible
Connie Ray Nana Possible
Todd Stashwick Doctor Drakken
Taylor Ortega Shego
Erica Tam[eng] Bonnie Rockwaller
Kiara Wilson Athena
Aissen Rain Brown Wade
Patton Oswalt Professor Dementor
Nancy Cartwright Rufus
Christy Carlson Romano Poppy Blue