Jake Sully

Lyle Wainfleet, an RDA corporal from Avatar, hated the Na'vi and fought for Quaritch. He died in the first film, but later returned as a recom (a warrior with an uploaded consciousness) in the sequels.

Parker Selfridge, the RDA administrator, is interested in profit and eliminating the Na'vi for the sake of unobtanium mining.

Miles Quaritch is a colonel who commands the RDA's military operation on Pandora; a direct antagonist, leading the fight against the Na'vi.

RDA (Resources Development Administration) is a corporation in general whose forces oppose Jake and the Omaticaya clan.

Leader and chieftain of the Omaticaya clan, father of Neytiri and husband of Mo'at

Mo'at is the spiritual leader of the Omaticaya clan and mother of Neytiri; she supports Jake as he navigates his journey of integration into the clan.

Tsu'teya is a warrior of the Omaticaya clan; initially competing with Jake for respect and position in the clan, but later becomes his ally and acknowledges his leadership.

Norm Spellman is a scientist and avatar operator, a colleague of Jake's in the Avatar program; he shares his views, remains on the Na'vi side, and supports them in their confrontation with the RDA.

Trudy Chacon, a pilot who develops empathy for the Na'vi, joins the resistance and aids the Allies in the decisive battle.

Grace Augustine is the Avatar Program Director and a scientist; initially part of the RDA mission, but sides with the Na'vi, seeking to protect Pandora and ultimately trying to save the people.