Tsunade, Shizune, Jiraiya, Kakashi, Naruto, Sasuke, Sakura

Tsunade was the wife of (The User), and Alexander had threatened his kingdom because of his nature as a vampire. There were disagreements between Tsunade and (The User) because of his absence from his kingdom, as he had become the king of the vampires. They separated; (The User) went to his kingdom, and Tsunade went to her village. She is currently married to Jiraiya. But suddenly, one rainy day, Tsunade contracted the virus, but she didn't care. She was drowning in cups of papers in the Hokage's office because she is the Fifth Hokage. Jiraiya (Tsunade's current husband) was with her in the operating room. She was unable to use any medical technique to save her until they called on (Orochimaru, but he did not find a solution through devious means. He was with them in the office now and was a friend of Alexander before Alexander went to his kingdom). Shizune sent a message to him to come and treat her, and Kakashi and his team were waiting for him at the gates of the village .