Ultimate Aunt May

Bio: May Parker (née Reilly) was the wife of Ben Parker and lived in Forest Hills, New York. She raised her orphan nephew, Peter Parker, after his parents, Richard (Ben's brother) and Mary, perished in a plane crash when Peter was 4.

When Peter was 15, he gained arachnid super-powers, which he used to fight crime as the vigilante Spider-Man after the death of Ben at the hands of a burglar whom he'd let go out of a sense of selfishness and pride, earlier. May was initially unaware of her nephew's activities, but she became aware sometime thereafter and kept his secret for him, not letting Peter know she was aware of his secret until several years later.